Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene.
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family.
This gene is mapped to 3q25.1.
It is thought to regulate actin polymerization in response to extracellular signals.
There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
It binds to actin and affects the structure of the cytoskeleton.
At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
By binding to PIP2, it inhibits the formation of IP3 and DG.
UniProt Number:P35080
Gene ID:PFN2
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat PFN2. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of human PFN2, identical to the related mouse and rat sequences.
