Neurotrophic tyrosine kinase, receptor, type 2 , also known as BDNF/NT-3 growth factors receptor or TrkB receptor, is a protein that in humans is encoded by the NTRK2 gene.
The TrkB receptor is part of the large family of receptor tyrosine kinases.
This gene is mapped to 9q21.33.
This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
Signalling through this kinase leads to cell differentiation.
Mutations in this gene have been associated with obesity and mood disorders.
Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term.
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 5mg BSA, 0.9mg sodium chloride, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg sodium azide. Reconstitute with 200ul of ddH2O to 0.5mg/ml.
Specificity：Recognizes human NTRK2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to a sequence at the N-terminus of human TrkB, aa70-90, EIFIANQKRLEIINEDDVEAY), different from the related mouse and rat sequences by 1aa.
