84-2098-21　NOS1 (Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS) 100ug　144979

特徴

• Nitric Oxide Synthase 1(NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain.
• It may be involved in neuronal cell death and damage in neurological illness.
• nNOS1 localized to the 12q24.2 region of human chromosome 12.
• It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids.
• nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2.
• Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length.
• The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle.
• The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity.
• Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.
• UniProt Number:P29475
• Gene ID:NOS1
• Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Handling:Store at -20˚C for one year.
• After reconstitution, store at 4˚C for one month.
• Can also be aliquoted and stored frozen at -20˚C for long term
• Avoid repeated freezing and thawing.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.