84-2098-16　NMDAR1 (Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1) 100ug　144971

特徴

• The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor.
• NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors.
• Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
• NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties.
• It consists of 21 exons distributed over about 31 kb.
• Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence.
• The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'.
• The gene is a candidate for the site of the mutation in torsion dystonia.The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell.
• NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.
• UniProt Number:Q05586
• Gene ID:GRIN1
• Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Handling:Store at -20˚C for one year.
• After reconstitution, store at 4˚C for one month.
• Can also be aliquoted and stored frozen at -20˚C for long term
• Avoid repeated freezing and thawing.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.