MYD88（MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88）, is a protein that, in humans, is encoded by the MYD88 gene.
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL1Rs).And it is mapped on 3p22.2.
MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.
This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways.
Qverexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter.
The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP.Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.
UniProt Number:Q99836
Gene ID:MYD88
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat MYD88. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence in the middle region of human MYD88, different from the related rat and mouse sequences by one amino acid.
