MATN3(Matrilin-3) is a protein that in humans is encoded by the MATN3 gene.
This gene encodes a member of von Willebrand factor A domain containing protein family.
This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues.
By fluorescence in situ hybridization, Belluoccio et al.
(1998) mapped the human MATN3 gene to chromosome 2p24-p23.
Wagener et al.
(2000) mapped the mouse Matn3 gene to the proximal end of chromosome 12, linked to the genes Synd1, Apob, Dtnb, and Kif3c.
The human homologs of all 5 of these genes map to 2p23, indicating considerable homology of synteny.
This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone.
Mutations in this gene result in multiple epiphyseal dysplasia.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.
Specificity：Recognizes human MATN3. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding aa466-486, NTKLDDILEKLKINEYGQIHR, at the C-terminus of human Matrilin 3.
