LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity.
It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit.
Additionally, LXR activity is critical for physiologic lipid metabolism and transport.
LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease.
Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression.
LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis.
The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.
UniProt Number:Q13133
Gene ID:NR1H3
Applications:Suitable for use in Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat LXRA/NR1H3. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of human LXRalpha, identical to the related rat and mouse sequences.
