HSP105（HEAT-SHOCK 105/110-KD PROTEIN 1）,also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene.
Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm.
Database analysis indicates that both HSP105 isoforms are highly conserved during evolution.
By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13.Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock.
HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses.
Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position.
Besides,HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.
UniProt Number:Q92598
Gene ID:HSPH1
Applications:Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat HSP105. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of human HSP105, different from the related mouse sequence by one amino acid, and different from the related rat sequence by two amino acids.
