84-2096-14 HSD11B1 (HSD11, HSD11L, HSD11B, SDR26C1, 11-DH, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11-BETA-HYDROXYSTEROID DEHYDROGENASE, TYPE I, short chain dehydrogenase/reductase family 26C, member 1) 100ug 144682
84-2096-14 HSD11B1 (HSD11, HSD11L, HSD11B, SDR26C1, 11-DH, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11-BETA-HYDROXYSTEROID DEHYDROGENASE, TYPE I, short chain dehydrogenase/reductase family 26C, member 1) 100ug 144682
11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.
In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.
It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers.
Tannin et al.
(1991) localized the HSD11B1 gene to chromosome 1.
The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe.
Schutte et al.
(2000) mapped the HSD11B1 gene to 1q32-q41.
UniProt Number:P28845
Gene ID:HSD11B1
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat HSD11B1. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.
