Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.
This gene product belongs to the histone deacetylase family.
Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4).
This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor.
Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Betz et al.
(1998) performed PCR using HDAC2-specific primers to screen a somatic cell hybrid mapping panel.
They mapped the HDAC2 gene to human chromosome 6q21, a region of the genome altered in some cancers, including retinoblastoma.
UniProt Number:Q92769
Gene ID:HDAC2
Applications:Suitable for use in Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
Specificity：Recognizes human HDAC2. Species Crossreactivity: rat. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa464-478, EDKSKDNSGEKTDTK at the C-terminal of human HDAC2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid. Species sequence homology: mouse.
