RIPK1 (Regulator of G Protein Signaling 3), also called RIP, is an enzyme that in humans is encoded by the RIPK1 gene.
Members of the TRAF protein family have been implicated in the activation of NF-kappa-B by the TNF superfamily.
By yeast 2-hybrid and coimmunoprecipitation studies using mammalian cell extracts, Hsu et al.
(1996) showed that RIP interacts with TRADD, TRAF1, TRAF2, and TRAF3.
Hartz (2012) mapped the RIPK1 gene to chromosome 6p25.2 based on an alignment of the RIPK1 sequence with the genomic sequence.
Stanger et al.
(1995) found that overexpression of Rip in mammalian cells induced morphologic changes characteristic of apoptosis.
They suggested that RIP may be an important element in the signal transduction machinery that mediates programmed cell death.
UniProt Number:Q13546
Gene ID:RIPK1
Applications:Suitable for use in Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human h.RIPK1. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：A synthetic peptide corresponding to a sequence in the middle region of human RIPK1.
