Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene.
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family.
By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32.
This gene is a crucial player in the regulation of plasma cholesterol homeostasis.
It may prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.
PCSK9 can induce ubiquitination of LDLR leading to its subsequent degradation.
This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.
UniProt Number:Q8NBP7
Gene ID:PCSK9
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human h.PCSK9. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of human PCSK9.
