CSF3R(Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.
G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).
The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.
The CSF3R gene consists of 17 exons.
By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.
(1991) localized the gene to 1p35-p34.3.
The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.
GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.
Dong et al.
(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation.
The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.
UniProt Number:Q99062
Gene ID:CSF3R
Applications:Suitable for use in Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human CSF3R. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：A synthetic peptide corresponding to a sequence in the middle region of human CSF3R.
