Dopamine receptor D1, also known as DRD1, is a human gene.
It is the most highly expressed DA receptor subtype among the DA receptor family.
Receptors for dopamine have been classified into two functional types, D1 and D2.
They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins.
D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases.
Dopamine D1 and D2 receptors are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism.
D1 receptors regulate neuron growth and differentiation, influence behaviour and modify dopamine D2 receptor-mediated events.
And the presence of a D1 receptor gene restriction fragment length polymorphism will be helpful for future disease linkage studies.
DRD1 also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.
UniProt Number:P21728
Gene ID:DRD1
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat DRD1. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence in the middle region of human DRD1, different from the related rat and mouse sequences by one amino acid.
