Decorin is a proteoglycan on average 90 - 140 kilodaltons (kD) in size.
The human decorin gene spans more than 38 kb and contains 8 exons and very large introns, 2 of which are 5.4 and more than 13.2 kb.
And the human decorin gene is mapped to 12q21.3.
It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS).
Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein.
Decorin and biglycan are thought to be the result of a gene duplication.
This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly.
And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping.
Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines.
There are multiple alternatively spliced transcript variants known for the decorin gene.
Mutations in the decorin gene are associated with congenital stromal corneal dystrophy.
UniProt Number:P07585
Gene ID:DCN
Applications:Suitable for use in Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat Decorin. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of human Decorin, identical to the related mouse sequence, and different from the related rat sequence by three amino acids.
