Connexin proteins oligomerize to form intercellular channels, called gap junctions, through which ions and small molecules move between adjacent cells.
Connexin 40(Gap junction alpha-5 protein) is a protein that in humans is encoded by the GJA5 gene.This gene is a member of the connexin gene family.
The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell.
Mutations in this gene may be associated with atrial fibrillation.
Alternatively spliced transcript variants encoding the same isoform have been described.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Heat induced antigen retrieval with 10mM sodium citrate buffer, pH 6.0 for 20 minutes is required for staining of formalin/paraffin sectionsOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul of sterile ddH2O.
Specificity：Recognizes human Connexin 40. Species Crossreactivity: mouse and rat. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa341-358, KRRLSKASSKARSDDLSV at the C-terminal of human Connexin 40, identical to the related mouse and rat sequence.
