Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle.
Human cell division is regulated primarily at the G1-to-S or the G2-to-M boundaries within the cell cycle.
The complexes formed by CDK4 and the D-type cyclins are involved in the control of cell proliferation during the G1 phase.
CDK4 is inhibited by p16, also known as cyclin-dependent kinase inhibitor-2.
CDK4 is mapped to 12q14.
CDK4 expression and activity are required for cytokine responsiveness in T cells.
UniProt Number:P30285
Gene ID:CDK4
Applications:Suitable for use in Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat CDK4. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of mouse CDK4, different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids.
