84-2093-40　CACYBP (S100A6-binding protein, Siah-interacting protein) 100ug　144255

特徴

• CACYBP(Calcyclin-binding protein), also called SIP, is a protein that in humans is encoded by the CACYBP gene.
• The full-length SIP cDNA encodes a predicted 228-amino acid protein.
• Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, SIP-short (SIPS).
• The CACYBP gene is mapped on 1q25.1.
• It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins.
• It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin.
• Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP protein function.
• UniProt Number:Q9HB71
• Gene ID:CACYBP
• Applications:Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.