BIRC4, baculoviral IAP repeat-containing protein 4 is also known as XIAP (X-linked inhibitor of apoptosis protein).
The BIRC4 gene comprises 6 exons.
This gene is mapped to chromosome Xq25.
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins.
Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function.
This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme.
This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.
Mutations in this gene are the cause of X-linked lymphoproliferative syndrome.
Alternate splicing results in multiple transcript variants.
Pseudogenes of this gene are found on chromosomes 2 and 11.
UniProt Number:P98170
Gene ID:XIAP
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat BIRC4. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the N-terminal of human BIRC4, different from the related mouse sequence by two amino acids.
