ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1),also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene.
The ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters.
The ABCC1 is a plasma membrane drug-efflux pump.The ABCC1 gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization.
ABCC1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Blocking ABCC1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that ABCC1 is an important protector in this scenario.
ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine.And Chemotaxis assays show that ABCC1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.
UniProt Number:P33527
Gene ID:ABCC1
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human, mouse and rat ABCC1. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the C-terminal of human ABCC1, different from the related rat and mouse sequences by one amino acid.
