84-2072-73　［取扱停止］SP1, CT (P692) (SP1, TSFP1, Transcription factor Sp1) (PE) 200ul　042180-PE

特徴

• Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli.
• Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.
• Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).
• Binds also the PDGFR-alpha G-box promoter.
• May have a role in modulating the cellular response to DNA damage.
• Implicated in chromatin remodeling.
• Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter.
• Plays an essential role in the regulation of FE65 gene expression.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and FLISA.
• Other potential application, though not tested is Direct Flow Cytometry.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.