EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides.
EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit.
There are four isoforms of EXOD1 that are produced as a result of alternative splicing events.
The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.
The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Applications:Suitable for use in Western Blot, FLISA
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：FLISA WB
Calc Crossreactivity：Hu
Immunogen：ERI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-472 amino acids from the Central region of human ERI2.
