CREBBP is an acetyltransferase enzyme that acetylates histones, giving a specific tag for transcriptional activation.
It also acetylates non-histone proteins, like NCOA3 coactivator.
This protein mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.
CBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.
Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias.
For example, MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
Defects in CREBBP are also the cause of Rubinstein-Taybi syndrome (RSTS).
RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Applications:Suitable for use in FLISA
Recommended Dilution:FLISA: 1:1,000
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：FLISA
Calc Crossreactivity：Hu
Immunogen：CREBBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169~199 amino acids from the N-terminal region of human CREBBP.
