Chromobox homolog 4 (CBX4 or Pc2) is a member of Drosophila Polycomb group gene family.
The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development.
Changes in expression pf PcG proteins have been associated with cancer.
CBX4 is a part of the cellular memory system that is responsible for the inheritance of gene activity by progeny cells.
CBX4 is involved in maintaining the transcriptionally repressive state of genes.
It modifies chromatin, rendering it heritably changed in its expressibility.
Structurally, CBX4 contains 1 chromo domain.
It was reported that Pc2 is involved in sumoylation process by recruiting SUMO E1 and E2, and Pc2 is actually SUMO E3 during sumoylation events.
CBX4 expression is ubiquitous.
Applications:Suitable for use in Western Blot, FLISA
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：FLISA WB
Calc Crossreactivity：Hu
Immunogen：CBX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415~444 amino acids from the C-terminal region of human CBX4.
