84-1963-98　［取扱停止］SLAMF7, ID (SLAMF7, CS1, SLAM family member 7, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, Membrane protein FOAP-12, Novel Ly9, Protein 19A, CD319) (Azide free) (HRP) 200ul　041779-HRP

特徴

• SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain.
• Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway.
• It may play a role in lymphocyte adhesion.
• Isoform 3 does not mediate any activation.
• SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
• SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea.
• Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines.
• The isoform 3 is expressed at much lower level than isoform 1.
• There are three named isoforms.
• Applications:Suitable for use in Western Blot, ELISA
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:100-500
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.