This gene encodes a member of the muscle segment homeobox gene family.
The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis.
The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways.
Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.
Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA