CREBBP is an acetyltransferase enzyme that acetylates histones, giving a specific tag for transcriptional activation.
It also acetylates non-histone proteins, like NCOA3 coactivator.
This protein mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.
CBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.
Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias.
For example, MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
Defects in CREBBP are also the cause of Rubinstein-Taybi syndrome (RSTS).
RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Applications:Suitable for use in ELISA
Recommended Dilution:ELISA: 1:1,000
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：CREBBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169~199 amino acids from the N-terminal region of human CREBBP.
