Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system.
Activated C1 cleaves C2 into C2a and C2b.
The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase.
Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration.
This gene localizes within the class III region of the MHC on the short arm of chromosome 6.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Applications:Suitable for use in Western Blot and ELISA.
Other applications have not been tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish peroxidase (HRP).
Specificity：Recognizes human C2. Species Crossreactivity: hamster
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hm Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 147-176 in the N-terminal region of human C2
