84-1862-45　［取扱停止］NeuroD1, NT (NEUROD1, BHLHA3, NEUROD, Neurogenic differentiation factor 1, Class A basic helix-loop-helix protein 3) (FITC) 200ul　038911-FITC

特徴

• NeuroD1 acts as a differentiation factor during neurogenesis.
• They are expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation.
• NeuroD1 is a basic helix-loop-helix (bHLH) protein contain 1 bHLH domain.
• NeuroD1 is a transcriptional activator, for efficient DNA binding it requires dimerization with another bHLH protein.
• It was reported that NeuroD1 involves heterodimerization with the ubiquitous bHLH protein E47, and regulates insulin gene expression by binding to a critical E-box motif on the insulin promoter.
• Defects in NEUROD1 causes maturity onset diabetes of the young type VI.
• MODY6 is a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and FLISA.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.