84-1807-29　［取扱停止］Ubiquitin, CT (UBC, Polyubiquitin-C, Ubiquitin) (FITC) 200ul　043544-FITC

特徴

• This gene encodes ubiquitin, one of the most conserved proteins known.
• Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover.
• Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.
• Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.
• This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence.
• Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat.
• Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and FLISA.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: Formalin fixed and paraffin embedded tissuesOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.