SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3.
H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation.
This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A.
SET2 binds DNA at promoters, and may act as a transcription activator.
SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin.
SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.
Applications:Suitable for use in Immunofluorescence, ICC, FLISA
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: FITC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：FLISA IF IHC
Calc Crossreactivity：Hu
Immunogen：SET2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21~50 amino acids from the N-terminal region of human SET2.
