84-1754-85　［取扱停止］BMPR2, NT (BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II) (Biotin) 200ul　032550-Biotin

特徴

• BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases.
• The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily.
• BMPs are involved in endochondral bone formation and embryogenesis.
• These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD.
• Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
• Mutations in BMPR2 have been associated with primary pulmonary hypertension.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other potential application, though not tested is Direct Flow Cytometry.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: Formalin-fixed, paraffin-embedded sectionsOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.