84-1712-25　［取扱停止］HLA-DPB1, ID (HLA-DPB1, HLA-DP1B, HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, MHC class II antigen DPB1) (Biotin) 200ul　036621-Biotin

特徴

• HLA-DPB belongs to the HLA class II beta chain paralogues.
• This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane.
• It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
• Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
• The beta chain is approximately 26-28 kDa and its gene contains 6 exons.
• Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
• Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:100-500Immunohistochemistry: 1:10-50
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.