This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five.
These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.
The gamma gene cluster includes 22 genes divided into 3 subfamilies.
Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes.
The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster.
Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region.
The constant region exons encode the common cytoplasmic region.
These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.
Alternative splicing has been described for the gamma cluster genes.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry (Not Tested) and ELISA.
Other applications have not been tested.
Recommended Dilution:Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes human PCDHGA3.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 284-311 in the central region of human PCDHGA3.
