This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.
The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.
Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone.
Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu
Immunogen：ESR1/ER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the Central region of human ESR1/ER.
