84-1702-49　［取扱停止］CAPN6, ID (CAPN6, CALPM, CANPX, Calpain-6, Calpain-like protease X-linked, Calpamodulin) (Biotin) 200ul　033183-Biotin

特徴

• Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases.
• The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits.
• The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains.
• Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress.
• The protein encoded by this gene is highly expressed in the placenta.
• Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains.
• The protein lacks critical active site residues and thus is suggested to be proteolytically inactive.
• The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:100-500Immunohistochemistry: 1:10-50
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.