84-1697-74　［取扱停止］TGFBR2, NT (TGFBR2, TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II) (Biotin) 200ul　042782-Biotin

特徴

• This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily.
• The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta.
• This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
• Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.
• Alternatively spliced transcript variants encoding different isoforms have been characterized.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: Paraformaldehyde-fixed paraffin embedded sections.
• Requires antigen retrieval using heat treatment prior to staining.
• Sodium citrate buffer, pH 6.0 is recommended
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.