PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders.
PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin.
The protein is found in high and low molecular mass forms.
Each consists of two chains, A and B.
The high molecular mass form contains a long chain A.
Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain.
The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis.
Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.
Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence, Flow Cytometry (Not Tested) and Immunohistochemistry.
Other applications have not been tested.
Recommended Dilution:Immunohistochemistry: Formalin-fixed, paraffin-embedded sectionsOptimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A/G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes human PLAU.
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 396-426 in the C-terminal region of human PLAU.
