ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes.
It seems to be required for cartilage and growth plate development.
This Type I membrane protein is expressed at high levels during early embryonic development.
The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
Defects in ROR2 are a cause of brachydactyly type B1 (BDB1).
BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails.
In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent.
Both fingers and toes are affected.
The thumbs and big toes are usually deformed.
Defects in ROR2 are a cause of recessive Robinow syndrome (RRS).
RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance.
The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Applications:Suitable for use in ELISA, Western Blot, Flow Cytometry (Not Tested), and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1,000ELISA: 1:1,000Immunohistochemistry: 1:10-1:50Flow Cytometry (Not Tested): 1:10-1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes human ROR2.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment within amino acids 19-50 in the N-terminal region of human ROR2, UniProt Accession #Q01974.
