84-1673-18　［取扱停止］PRL1 (Protein Tyrosine Phosphatase Type IVA 1, Protein-tyrosine Phosphatase 4a1, Protein-tyrosine Phosphatase Of Regenerating Liver 1, PRL-1, PTP(CAAXI), PTP4A1, PTPCAAX1) (Biotin) 200ul　P9109-45Y-Biotin

特徴

• The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif.
• PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes.
• This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane.
• The surface membrane association of this protein depends on its C-terminal prenylation.
• Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis.
• Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase.
• PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1,000 Western Blot: 1:100-1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.