84-1669-97　SQSTM1, CT (p62) Sequestosome-1, Phosphotyrosine-independent Ligand for the Lck SH2 Domain of 62kD, Ubiquitin-binding Protein p62, EBI3-associated Protein of 60kD, p60, EBIAP, ORCA, OSIL) (Biotin) 200ul　S0961-50A-Biotin

特徴

• SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.
• This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination.
• This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
• SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates.
• Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
• Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry: Formalin-fixed, paraffin-embedded sectionsOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
• Note: Applications are based on unconjugated antibody.