特徴

• HFE2 is involved in iron metabolism.
• It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression.
• It could also represent the cellular receptor for hepcidin.
• Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
• Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH).
• JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
• Applications:Suitable for use in Western Blot and Indirect Flow Cytometry.
• Other applications have not been tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.