84-1611-49　［取扱停止］SNRPN, NT (SNRPN, HCERN3, SMN, Small nuclear ribonucleoprotein-associated protein N, Sm protein D, Sm protein N, Tissue-specific-splicing protein) (APC) 200ul　042103-APC

特徴

• The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family.
• The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events.
• Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown.
• The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF).
• Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region.
• Additional splice variants have been described but sequences for the complete transcripts have not been determined.
• The 5' UTR of this gene has been identified as an imprinting center.
• Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, FLISA
• Recommended Dilution:FLISA: 1:1,000Western Blot: 1:100-500Immunohistochemistry: 1:10-50
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.