84-1578-13　［取扱停止］TOB1, NT (Protein Tob1, Transducer of erbB-2 1, TROB1, TOB) (APC) 200ul　T7948-10-APC

特徴

• TOB1 is a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth.
• When exogenously expressed, this protein supresses cell growth in tissue culture.
• The protein undergoes phophorylation by a serine/threonine kinase, 90kD ribosomal S6 kinase.
• Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression.
• This protein inhibits T cell proliferation and transcription of cytokines and cyclins.
• The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity.
• This interaction inhibits interleukin 2 transcription in T cells.
• Applications:Suitable for use in FLISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:FLISA: 1:1,000Western Blot: 1:100-1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.