84-1553-39　［取扱停止］CDK5R1(p35), NT (Cyclin-dependent kinase 5 activator 1 [Precursor], CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, Tau protein kinase II 23kD subunit, p23, TPKII regulatory subunit, Cyclin-dependent kinase 5 activator 1, p35, Cyclin-dependent kinase 5 activator 1, p25, CDK5R1, CDK5R, NCK5A) (AP) 200ul　033670-AP

特徴

• p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system.
• The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form.
• The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions.
• P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.
• The p25 form accumulates in the brain neurons of patients with Alzheimer's disease.
• This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
• Applications:Suitable for use in Immunohistochemistry, ELISA
• Recommended Dilution:ELISA: 1:1,000Immunohistochemistry: 1:10-50
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.