84-1552-41　［取扱停止］XRCC6, ID (G22P1, X-ray repair cross-complementing protein 6, 5'-deoxyribose-5-phosphate lyase Ku70, 70kD subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70kD subunit, CTC box-binding factor 75kD subunit, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Thyroid-lupus autoantigen, X-ray repair complementing defective repair in Chinese hams ...　043936-AP

特徴

• Ku70 is a single stranded DNA-dependent ATP-dependent helicase.
• It has a role in chromosome translocation.
• The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner.
• It works in the 3'-5' direction.
• Binding to DNA may be mediated by p70.It is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.
• The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold.
• The Ku p70/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:50-100Immunohistochemistry: 1:50-1001:10-50
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.