This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation.
The complement pathway plays an essential role in the innate and adaptive immune response.
The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins.
This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2.
The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation.
A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.
Alternate splicing results in multiple transcript variants.
Applications:Suitable for use in Western Blot, ELISA
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：MASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-507 amino acids from the Central region of human MASP1.
