Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths.
Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration.
Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia.
The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3.
These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III).
OTOP1 was the first described member of the Otopetrin family.
Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal.
OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.
Applications:Suitable for use in Western Blot, ELISA
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：OTOP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the Central region of human OTOP2.
