The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes.
The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments.
Through its rod domain, this protein forms complexes with envoplakin.
This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments.
AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
[provided by RefSeq].
Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：PPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1300-1331 amino acids from the C-terminal region of human PPL.
