SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3.
H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation.
This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A.
SET2 binds DNA at promoters, and may act as a transcription activator.
SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin.
SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：SET2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21~50 amino acids from the N-terminal region of human SET2.
